Among 33 protein coding genes in the EOAD-associated region based on the Ensembl gene annotation (S5 Table), EPS8L2 (Ensembl gene ID: ENSCAFG00000025183) was of particular interest because this gene was identified as a putative causal gene for hearing loss in consanguineous families in humans [31, 32]. This evidence concerns the gene EPS8L2 and hearing loss disorder.