TNF and COVID-19: Data from registries such as the COVID-19 Global Rheumatology Alliance and Surveillance Epidemiology of Coronavirus Under Research Exclusion (SECURE-IBD) helped to identify the ineffectiveness of hydroxychloroquine as a prophylactic therapy for infection with SARS-CoV2 (110) and the potential importance of therapies targeting TNF and IL-6 (111, , , –115).