In the case of CRP, it displayed a negative correlation after correction with obsessive-compulsive disorder (OCD), anorexia nervosa (AN), and cognition, as well as a trend toward a negative correlation with SZ (P = 1.7 × 10−3), while its correlation with post-traumatic stress disorder (PTSD), major depressive disorder (MDD), and attention-deficit/hyperactivity disorder (ADHD) was strongly positive. This evidence concerns the gene CRP and major depressive disorder.