CD8A and autoimmune disease: Among patients with the same autoimmune diseases, men have a more diverse T-cell receptor–variable β chain on CD8+ T cells than women, suggesting that male patients could develop more CD8+ T-cell clones in response to the same antigen stimulation.27 It can be assumed that, in the context of allogenic HSCT, donor cytotoxic T lymphocytes may yield greater variety in male recipients when encountering allogeneic antigens.