They are Apolipoprotein B mRNA Editing Catalytic Polypeptide-like (APOBEC)-mediated mutations, what might explain their overrepresentation in bladder cancer as compared to other FGFR3 alterations.(2) Our sample size was small and we could identify only these two cases; however, this finding is in accordance with those of larger cohorts. The gene discussed is APOB; the disease is urinary bladder cancer.