IDO1 and leprosy: Intriguingly, such changes in IDO-1 and nutritional metabolism are also found in leprosy (38), and we have recently described at the cellular level a close parallel of gene expression in macrophages infected in vitro with L. donovani (48) with that described for macrophages infected with M. leprae (49), including the induction of Type-I IFNs and OASL2.