We herein describe the clinical history of two patients affected by atypical progeroid syndrome (APS) and partial lipodystrophy caused by a heterozygous missense lamin A/C gene (LMNA) mutation c.1045 C > T (p.R349W), who experienced a clinically significant worsening of their underlying cardiovascular diseases following SARS-CoV-2 infection. The gene discussed is LMNA; the disease is partial lipodystrophy.