In the spinal cord, classical ependymomas (WHO grade 2 and 3) and myxopapillary ependymomas (WHO grade 2) predominate among adults and thus far are not stratified molecularly: they are often relatively indolent tumors, while a rare and highly aggressive subgroup with a propensity to disseminate, affecting young adults and adolescents, the spinal ependymoma, MYCN-amplified, has been recently identified [18, 19•]. This evidence concerns the gene MYCN and ependymoma.