Given that sex influences stroke outcome (Manwani et al., 2013) and aging alters the polarization of both γδ T cells (Chen et al., 2019) and astrocytes (Clarke et al., 2018) towards a proinflammatory phenotype, the exclusive use of young male mice throughout the present study is another shortcoming that should be addressed in future studies to achieve an even deeper understanding of specific IL-1 effects. Here, IL1B is linked to stroke disorder.