In line with Trizol whole-brain mRNA data, Cxcl1 and Cxcl2 levels were profoundly ﻿reduced in Il1−/− mice 24 h after stroke, whereas Ccl2 was not significantly downregulated in input material from Il1−/− mice (Supplemental Fig. 1A). The gene discussed is IL1B; the disease is Stroke.