The reduced infarct volume was paralleled by a reduced motorsensory deficit 24 h after pMCAO: In WT littermates, mean total grip strength post-stroke was significantly reduced by 15% on average compared to baseline measurements, whereas it was not significantly diminished in Il1−/− mice, indicating that IL-1 deficiency improves functional outcome following pMCAO (Fig. 1C). This evidence concerns the gene IL1A and stroke disorder.