All together, we propose that IL-1 exerts its early detrimental effects in ischemic stroke via IL-17A induction in γδ T cells and that IL-1 and IL-17A signaling converge on astrocytes which in turn produce CXCL1 leading to neutrophil infiltration and subsequent amplification of the post-ischemic inflammatory reaction. This evidence concerns the gene IL1A and ischemic stroke.