IL-1 signaling in brain endothelial cells was shown to play a crucial role in mediating neutrophil recruitment after stroke since mice with brain endothelial cell-specific IL-1R1 deletion showed almost a complete loss of neutrophil infiltration following tMCAO (Wong et al., 2019) comparable to the effects seen in Il1−/− mice in the present study. This evidence concerns the gene IL1B and stroke disorder.