Some researchers39 still doubted the use of C‐peptide to correct endogenous insulin because some PK parameters were not consistent (eg, a peak of glargine in plasma occurring at 12 hours40 differs from those observed in subjects with type 1 diabetes where the increase occurs between ≈3 and 6 hours after the first injection41 and at steady state42). The gene discussed is INS; the disease is type 1 diabetes mellitus.