According to the IVW method, we found that per 10% increase in log‐transformed adiponectin level was significantly associated with a decreased risk of GAC (OR = 0.88, 95% CI 0.81, 0.96), whereas with an increased risk of HCC (OR = 1.26, 95% CI 1.09, 1.44) and of BTC (OR = 1.54, 95% CI 1.12, 2.12) (Table 1). The gene discussed is ADIPOQ; the disease is hepatocellular carcinoma.