In women with PCOS, 10‐h GM LH pulse frequency increased by 14% (95% CI, −6–37%; p = 0.168) and 8% (95% CI −10–31%; p = 0.383) with placebo and progesterone administration, respectively, with no significant difference between placebo and progesterone (ratio of GM ratios 0.95 [95% CI 0.76–1.20]; p = 0.672). This evidence concerns the gene PLOD1 and polycystic ovary syndrome.