In this study, 12 h of progesterone exposure may have been insufficient for progesterone to have its full negative feedback effect on the GnRH pulse generator, and it is possible that a longer duration of progesterone (e.g., 24–72 h of exposure) might disclose differences in the rapidity of progesterone‐related suppression of LH pulse frequency in PCOS vs. controls. Here, PLOD1 is linked to polycystic ovary syndrome.