Controls exhibited a significantly greater increase in FSH AUC with progesterone versus placebo administration (ratio of GM ratios 1.53 [95% CI, 1.21–1.93]; p = 0.001), as did women with PCOS (ratio of GM ratios 1.35 [95% CI, 1.07–1.71]; p = 0.014). Here, BRD2 is linked to polycystic ovary syndrome.