Interestingly, we showed that the downregulation of the hnRNP G‐T‐ZDHHC11 mRNA pathway, which was highlighted as upstream signaling of the ATM/ATR pathway by our transcriptome analysis, inhibited the growth suppression effect in cancer cells, but not in non‐cancerous cells, suggesting that the antitumor effects of ATM/ATR signaling‐targeted therapy may be achieved by targeting hnRNP G‐T or ZDHHC11, with fewer adverse events. This evidence concerns the gene TBXT and cancer.