Resveratrol was evaluated against rhabdomyosarcoma soft tissue malignant tumour cells and was found to decrease cell growth, reduce cells in the S phase, arrest G0/G1 transition and reduce TGF‐β1and Smad4 expression at the protein and mRNA levels in PLA‐802 human alveolar rhabdomyosarcoma cell.195. This evidence concerns the gene SMAD4 and rhabdomyosarcoma.