PVR and hepatocellular carcinoma: To further explore the downstream signalling pathway of CD155 in HCC, we used RNA‐seq to identify differentially expressed genes (DEGs) between CD155 knockdown MHCC97H cells and control MHCC97H cells (n = 3 in each group), and 210 upregulated genes and 69 downregulated genes were identified in CD155 knockdown cells (p < .05, |log2FoldChange| > 1) (Figure 5A).