The direct Wnt/β‐catenin signalling target genes, such as transcription factor 7 like 2 (TCF7L2), wnt1‐induced secreted protein 1 (WISP1), GLP1 and peroxisome proliferator‐activated receptor delta (PPARδ), play major roles in obesity and diabetes.7 The gene discussed is GCG; the disease is diabetes mellitus.