The roles of the Wnt/β‐catenin signalling suppressor Cxxc5 in metabolic disease‐related phenotypes were confirmed in the epiWAT of HFD‐fed Cxxc5−/− mice, which had smaller adipocytes and decreased expression levels of F4/80, Cd11b proinflammatory markers in the CLSs with decreased and increased expression of M1 and M2 macrophage markers, respectively (Figures 2F and G and S6A and B). Here, CXXC5 is linked to Other metabolic disease.