The improvement of overall metabolic dysfunction by controlling Cxxc5 function either by the CXXC5‐Dvl PPI inhibitor or by Cxxc5 knockout could be achieved by the restorative inductions of multiple Wnt/β‐catenin pathway target genes involved in adult stem cell activation, especially those related to pathophysiological roles in metabolic diseases.7, 26, 27. Here, CXXC5 is linked to Other metabolic disease.