In multivariate analysis, male sex: aSHR 1.40 (95% CI 1.11–1.78), lower baseline CD4 (<100 cells/mm3, aSHR: 2.08, 95% CI 1.47–2.92, 101–200 cells/mm3, aSHR: 2.21, 95% CI 1.54–3.16), 201–350 cells/mm3, aSHR: 1.59, 95% CI 1.11–2.28 vs. >350 cells/mm3), lower baseline body weight (<50 kg, aSHR: 1.52, 95% CI 1.17–1.95) and prior TB event (aSHR: 3.50, 95% CI 2.72–4.52) were significantly associated with TB incidence. The gene discussed is CD4; the disease is tuberculosis.