Additionally, the pathways of positively selected genes were notably enriched in metabolic pathways, PI3K-Akt signaling pathway, NF-κB signaling pathway, pathways in cancer, MAPK signaling pathway, TNF signaling pathway, Jak-STAT signaling pathway, mTOR signaling pathway, FoxO signaling pathway, fatty acid metabolism, IL-17 signaling pathway, cholesterol metabolism, Tah17 cell differentiation, and so on (Supplementary Table S18), which were mainly associated with immunity, energy metabolism, and cell growth and differentiation. Here, AKT1 is linked to cancer.