For example, mutations in the protein doublecortin (DCX in humans, Dcx in mouse), which is a regulator of both growth cone F-actin and MT organisation (Deuel et al., 2006; Friocourt et al., 2003; Fu et al., 2013; Jean et al., 2012; Tint et al., 2009), cause neurodevelopmental lissencephaly (Wynshaw-Boris et al., 2010). The gene discussed is DCX; the disease is lissencephaly spectrum disorders.