Genome-wide association studies (GWAS) of CSF biomarkers in AD case/control samples have found loci in genes GEMC1 and OSTN23 as well as more commonly reported loci such as the TREM cluster, APOE, APOC and TOMM40.24 However, these have also only focused on small sets of biomarkers, typically P-tau181 and Aβ42. The gene discussed is APOE; the disease is Alzheimer disease.