WWOX and Alzheimer disease: The second genome-wide significant region was on chromosome 16 in the WWOX gene (chr16:78 133 327–79 246 564), which has also been linked to AD by GWAS.35 The lead SNP rs34946778 (chr16:78989116, B = 0.15, SE = 0.026, P = 4.36 × 10−9) was not statistically significant in the AD GWAS.35 The linkage disequilibrium was r2 = 0.0014 between the AD GWAS lead SNP (rs62039712) and the SNP identified in our study (rs34946778).