In addition, a SIRT1-plasmid was used to treat rats with CH, and the results indicated that the SIRT1-plasmid could increase SIRT1 expression in the CH rats, enhance fT4 levels and reduce TSH levels in the plasma of CH rats, improve rat behavior, and reduce CH-induced nerve cell apoptosis. The gene discussed is SIRT1; the disease is cyclic hematopoiesis.