It has been reported that curcumin derivative C66, an inhibitor of JNK phosphorylation, can reduce the high-glucose-activated JNK/NF-κB pathway in diabetic cardiomyopathy mice, thereby reducing the inflammatory response and apoptosis process and delaying the process of diabetic cardiomyopathy [31]. The gene discussed is NFKB1; the disease is diabetic cardiomyopathy.