Diabetic cardiomyopathy is associated with a variety of signaling pathways, such as AMPK, Nrf2-ARE signaling pathway, Wnt/β-catenin signaling pathway, NF-κB signaling pathway, TGF-β1/Smads signaling pathway, PKC signaling pathway and PI3K/AKT signaling pathway [30]. This evidence concerns the gene AKT1 and diabetic cardiomyopathy.