TARDBP and autosomal recessive limb-girdle muscular dystrophy type 2A: However, TDP-43 aggregates have also been found in skeletal muscles of patients with inclusion body myositis (IBM)8,9, oculopharyngeal muscular dystrophy (OPMD)10 and limb-girdle muscular dystrophy type 2a (LGMD2a)11 suggesting that TDP-43 aggregation may play a prominent pathological role also in muscle tissue.