We found that the albumin and uric acid levels were decreased in all of the NFD groups as compared with the control, indicating clearly that the protein deficiency led to malnutrition of animals in NFD treatments because low albumin and uric acid levels in serum indicating a poor nutritional status14 and efficiency of protein retention15,16, respectively. Here, ALB is linked to hereditary thrombophilia due to congenital protein S deficiency.