BNIP3 and Hyperglycemia: As shown in Fig. 5, treatment of HG cardiomyocytes with EVs derived from ticagrelor pretreated- H9c2 cells resulted in the inhibition of the expression of autophagy markers Beclin (Fig. 5a) and Bnip3 (Fig. 5b), which are drastically upregulated depending on the hyperglycemia.