Interestingly, the overall abdominal aortic diameter was smaller and transmural rupture was decreased in hyperlipidemic Plpp3+/− mice after AngII infusion (Fig. 2C,D; P < 0.05), although there was no difference in the overall incidence of aneurysm formation, as defined by a greater than 50% increase of abdominal aortic diameter from baseline to post AngII (Fig. 2E). This evidence concerns the gene PLPP3 and aneurysm.