FGFR1 and neoplasm: Consistent with these observations, we tested the FGFR1 inhibitor BGJ398 for growth inhibition in four randomly selected FGFR1-amplified tumors (PHLC-200, −274, −299, and −321), and found that in all cases there was an initial minor shrinkage of tumors but ultimately no inhibition of PDX tumor growth (Supplementary Fig. 7D–G).