Additionally, SNHG12, E2F7, p/t-MEK, and p/t-ERK expression pattern in tissues was reduced prominently whereas miR-129-5p expression pattern was increased when tumor-bearing mice were treated with EVs-sh-SNHG12 in comparison to EVs-sh-NC (Fig. 6A, B and Fig. S3E). This evidence concerns the gene MAP2K7 and neoplasm.