GABRB3 and epilepsy: In summary, functional analysis of GABRB3 epilepsy-associated variants, as measured by GABA sensitivity and maximum GABA current amplitudes, clearly demonstrated that two distinct functional categories of GABAA receptors were identified: an unexpected GOF receptor characterized by an increase in GABA sensitivity without significant reduction in maximum GABA amplitude and the classical LOF receptor, characterized by a decrease in GABA sensitivity with or without a reduction in maximum GABA amplitude.