Successful establishment of the cardiac hypertrophy model was confirmed by an obviously increased protein expression level of ANP, BNP, β-MHC and Ythdf2 in western blot (Fig. 1G) and a clearly increased relative mRNA expression level of ANP, BNP, β-MHC, Ythdf2, and MIAT in RT-qPCR (Fig. 1H). This evidence concerns the gene NPPA and cardiac hypertrophy.