By interfering with the expression level of m6A methylase with various techniques, for example, overexpress METTL3 with adenovirus, transfect METTL3 siRNA, and use METTL3 and FTO knockout mice, etc., researchers found that the cardiac m6A RNA modifications could regulate gene expression and influenced cardiac hypertrophy [13]. Here, METTL3 is linked to cardiac hypertrophy.