We found that overexpression of DUB3 in Hep3B and HepG2 cells considerably enhanced KLF4 protein expression (Fig. 5A) and resulted in lower IC50 values of doxorubicin hydrochloride and cisplatin, respectively, compared with control (Fig. 5B), suggesting that DUB3 enhances chemosensitivity of HCC cells possibly via KLF4. This evidence concerns the gene KLF4 and hepatocellular carcinoma.