To confirm the existence and stability of circ_6014 in breast cancer, we treated MDA-MB-231 and MCF-7 cells with actinomycin D, which can inhibit transcription, and observed that the level of linear ILKAP was decreased, while the circ_6014 level was maintained over time (Figure 1J, 1K). The gene discussed is ILKAP; the disease is breast cancer.