GBP2 and colorectal carcinoma: In addition, Guinney et al proposed a robust classification system that can classify CRC into four CMS with distinctive features: CMS1 (MSI immune); CMS2 (canonical); CMS3 (metabolic) and CMS4 (mesenchymal).23 We found that the CMS1 subtype showed the highest GBP2 expression, whereas the CMS2 subtype showed the lowest GBP2 expression (figure 2F).