In CRC, only one study has demonstrated that upregulating of GBP2 could inhibit the growth of CRC and increase the sensitivity of paclitaxel-resistant CRC cells to paclitaxel.12 The current study sheds light on the high correlation of GBP2 with high CD8 +T cell infiltration, APM and chemokine (C-X-C motif) ligand 10/11 (CXCL10/11) expression, and better PD-1 blockade response through several well-established biological algorithms, in vitro and in vivo experiments. Here, PDCD1 is linked to colorectal carcinoma.