STAT1 has been reported to be a favorable prognostic biomarker in CRC.48 Meanwhile, high levels of CD8 +T cells were found in a subpopulation of pMMR CRC patients that were positive for PD-L1 and p-STAT1.35 Our TMA cohort also showed a higher PD-L1 positivity rate in the high GBP2 expression group. This evidence concerns the gene CD274 and colorectal carcinoma.