YTHDF2 and leukemia: Specifically, knockdown of YTHDF2 was found to lead to the upregulation of TNF receptor superfamily member 1b (TNFRSF1B), which encodes TNF receptor 2 (TNF-R2), by extending the half-life of m6A-modified TNFRSF1B transcripts in leukemia cells [38, 63].