All four VDR polymorphisms were not associated with the risk of BPH under the dominant model: Taq-I: OR 1.16, 95% CI (0.95–1.42) for TT + Tt vs. tt; Bsm-I: OR 1.05, 95% CI (0.80–1.39) for BB + Bb vs. bb; Apa-I: OR 1.07, 95% CI (0.77–1.51) for AA +Aa vs. aa; Fok-I: OR 0.90, 95% CI (0.78–1.04) for FF + Ff vs. ff and recessive model (Taq-I: OR 1.36, 95% CI (0.91–2.02) for tt vs. TT; Bsm-I: OR 1.34, 95% CI (0.90–1.99) for bb vs. BB; Apa-I: OR 1.23, 95% CI (0.57–2.64) for aa vs. AA; Fok-I: OR 0.76, 95% CI (0.54–1.07) for ff vs. FF) (Table 2, Supplementary Figs. S3A–S6A). This evidence concerns the gene VDR and benign prostatic hyperplasia.