PPFIA4 and neoplasm: In contrast, PPFIA4 depletion in C4-2B xenografts grown in castrated nude mice resulted in delayed tumor progression, with the mean tumor volume at 620±105.2 mm3 in C4–2B-shPPFIA4 xenografts but 1363±268.5mm3 in the control group (Fig. 3K-L).