When castrated mice carrying LNCaP or VCaP xenografts (vector and PPFIA4) were treated with DS18561882, the inducible effects of PPFIA4 on tumor growth could hardly be detected, as evidenced by tumor growth (Fig. 7C; Supplementary Fig. S7B), tumor volume (Fig. 7D; Supplementary Fig. S7C), and the proliferation index Ki67 (Fig. 7E; Supplementary Fig. S7D). Here, MKI67 is linked to neoplasm.