Moreover, Zhou and colleagues used a whole-blood multicolor flow cytometry in patients with metastatic cancers to identify a liquid immune profile signature based on five cell subtypes significantly associated with a better OS: CD14high monocytes, CD8 + /PD-1+ T cells, plasmacytoid dendritic cells, neutrophils, and CD3+/CD56+/CD16+ natural killer T cells. Here, NCAM1 is linked to metastatic malignant neoplasm.