However, upregulation of CD206, an anti-inflammatory cell surface marker, was solely observed in secondary tumor-bearing MMTV-Wnt1 mice, and not primary tumor or non-tumor bearing mice (Fig. 1e), indicating that potential soluble factors secreted by secondary tumors may activate microglia and promote anti-inflammatory/pro-tumorigenic properties. This evidence concerns the gene WNT1 and neoplasm.