Besides, current MR studies have suggested a causal relationship between inflammatory and immune factors, such as CCL2, NFKB1 [44], IL2Rα [45] and the predisposition to MS, which further indicates that the disorder of inflammatory and immune processes may exert a significant impact on the development of MS, considering the important role of microglia. Here, NFKB1 is linked to myeloid sarcoma.