Circ-IRAS enters microvascular endothelial HUVECs via exosomes from PC cells, downregulates miRNA-122 and ZO-1, upregulates RhoA and RhoA-GTP, increases F-actin expression and focal adhesion, increases the permeability of endothelial monolayer, and promotes tumor invasion and metastasis [38]. This evidence concerns the gene RHOA and neoplasm.