AFP and hepatocellular carcinoma: For instance, circRNA-5692 suppresses the malignant progression of HCC via sequestering miR-328-5p to up-regulate DAB2IP expression [9]; circRNA-SORE improves the stability of YBX1 by mediating sorafenib resistance in HCC [10]; circRNA_104348 facilitates HCC malignancy by regulating miR-187-3p/RTKN2 axis [2]; circRHOT1 propels the development of HCC via initiating the expression of NR2F6 [11]; and circRNA Cdr1as as a competitive endogenous RNA (ceRNA) sponges miR-1270 to up-regulate AFP expression, thereby facilitating the development of HCC [12].