CircZNF609 facilitates the proliferation, metastasis and stemness of HCC via the activation of the Hedgehog pathway by regulating the expressions of miR-15a-5p, miR-15b-5p and GLI2 [17]; KLF2 attenuates the progression of HCC by negatively modulating the Hedgehog pathway [18]; Sesn3 ablation propels carcinogen-induced HCC via modulation of the Hedgehog pathway [19]; MIRLET7BHG facilitates the progression of HCC through the activation of hepatic stellate cells by activating Hedgehog pathway [20]; and circIPO11 drives the proliferation of HCC via Hedgehog signaling pathway [21]. This evidence concerns the gene GLI2 and hepatocellular carcinoma.