KDR and gastroesophageal junction adenocarcinoma: The phase 2 results of RAMSES trial showed that the addition of vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor ramucirumab to neoadjuvant FLOT for patients with locally advanced esophagogastric adenocarcinoma significantly increased R0 resection rate with no improvement in pCR [19].