Compared with that in the sham group, the expression of CX3CR1/FKN in the sp5c was increased in the migraine group and further increased in the comorbidity group (Fig. 3D-E; FCX3CR1 = 21.29, P < 0.001; FFKN = 24.12, P < 0.001). Here, CX3CR1 is linked to migraine disorder.