SOX2 and cancer: Stem cell potency-associated members were applied for expression identification using the CBIOPORTAL, and the profiled patterns of different studies are shown in Figure 2, which has emphasized a good concordance of the four members of PGP9.5, SOX2, TP53 and CAGE with the surface markers of cancer stem cells of either PROM1, CD44 or ALDH1A1.