We applied to the determination of esophageal cancer patients andfound that as shown, P53, PGP9.5, SOX2, CAGE, according to the results of quantitative of the signatures-associated antibodies in esophageal cancer-related levels also higher than that of benign disease and healthy people group, which shows that as one of the esophageal serologic test indicators, SOX2 can not only better screening in high-risk groups, but also finding the potential for patients with esophageal cancer (Table 5). Here, SOX2 is linked to esophageal cancer.