It was recently shown that in human IDH mutant gliomas, hypermethylation at cohesin and CCCTC-binding factor (CTCF)-binding sites compromised its binding with the methylation-sensitive CTCF insulator protein, resulting in an aberrant interaction of an enhancer with the receptor tyrosine kinase gene PDGFRA, which is a known glioma oncogene. Here, IDH2 is linked to central nervous system cancer.