Moreover, 88 of the 2C differential dependencies are in the COSMIC Cancer Gene Census (CGC)52 (p ≤ 0.001)—including BRAF, KRAS, NRAS, and PIK3CA (Figure S2)—a significantly higher proportion than for non-2C genes (2C: 17.2%, non-2C: 11.2%, p ≤ 0.001; two-sample proportion test). The gene discussed is PIK3CA; the disease is cancer.