Consistent with these reports, MYC expression is higher in myeloma cell lines than other cancer types (p ≤ 0.001, Wilcoxon rank-sum test) and is significantly correlated with dependency on TCF3 and IRF4 (TCF3: R = −0.13, p ≤ 0.001, IRF4: R = −0.14, p ≤ 0.001; Pearson correlation, Figure S7). This evidence concerns the gene IRF4 and plasma cell myeloma.