Including measures of baseline AD-related pathology and APOE status in the model revealed that both AD-related pathology (F1,233 = 3.277, P = 0.072, CI95% = (−0.041, 0.002)) and APOE status (F1,234 = 3.057, P = 0.082, CI95% = (−0.040, 0.002)) marginally interacted with time and age in predicting changes in CDR-SB (Fig. 5c,d), while changes in brain system segregation significantly interacted with time and age in predicting changes in CDR-SB (F1,242 = 7.957, P = 0.005, CI95% = (−0.052, −0.010); Fig. 5b). The gene discussed is APOE; the disease is Alzheimer disease.