DBT and cardiac hypertrophy: After infusing the animal models with ANG-II, which is a known potent vasoconstrictor, they found that animals lacking E2-β showed increased hypertrophy as compared to WT and E2-ɑ KO, thus, indicating the important role of E2-β on cardiac hypertrophy, whereas E2-ɑ did not seem to play a significant role in cardiac hypertrophy [29].