GPER: G-protein coupled estrogen receptor: eNOS: endothelial nitric oxide synthase; G-1: selective GPER agonist; GPERKO: G-protein coupled receptor knockout; Akt: protein kinase B; PI3K: phosphoinositide-3-kinase; LDL: low-density lipoproteins; mPTP: mitochondrial permeability transition pore; PD: Erk inhibitor; HTN: hypertension; NO: nitric oxide; ISO: immobilization stress; ERK: extracellular-signal-regulated kinase. The gene discussed is GPER1; the disease is Hypertension.