Left ventricular outflow tract (LVOT) obstruction occurs in 15%-25% of TC patients leading to heart failure [22]. Westphal et al. (2012) studied the effect of E2, 16-ɑ LE2 (selective E2-ɑ agonist), and raloxifene on transverse aortic constriction (TAC) induced myocardial hypertrophy. Here, DBT is linked to cardiac hypertrophy.