TTN and peripartum cardiomyopathy: Currently, the two-hit model of peripartum cardiomyopathy is considered to be appropriate with a vascular humoral insult along with genetic predisposition [9]. Multiple genetic targets play an essential role in developing peripartum cardiomyopathy including titin protein (TTN), BCL2-associated athanogene 3 (BAG3), parathyroid hormone-related protein (PTHLH), and peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α) [9,10].