IL-1β secreted by tumor-activated monocytes promoted the development of IL-17–producing CD8+ T-cell (Tc17) populations and the supernatants induced the production of the chemokine CXCL12 by tumor cells and led to functional impairment of antitumor CD8+ cytotoxic T-cells [37]. The gene discussed is CXCL12; the disease is neoplasm.